Endocrine Abstracts

Abstract: A 32-year-old lady presented to us at 6 months of gestation with parathyroid hormone (PTH) -dependent hypercalcemia mediated pancreatitis and endogenous insulin dependent hypoglycemia, owing to parathyroid adenoma and possibly insulinoma, respectively. The parathyroid adenoma was localized on the MRI of the neck; however, no imaging for the insulinoma could be done due to the gravid state. Due to the simultaneous occurrence of tumors in two endocrine glands, namely, ...

Background: The geographical difference in presentation of primary hyperparathyroidism (PHPT) is well known however, there is spare literature on influence of age and gender on presentation of PHPT.Objective: To study the effect of age and gender on clinical and biochemical presentation of PHPT.Method: This is a retrospective analysis of 184 histopathologically proven PHPT patients between March 1990 and March 2010 from a single ce...

Aim: To determine the HbA1c cut-offs for diagnosis of prediabetes based on isolated IFG, isolated IGT and both IFG and IGT.Methods: Cross-sectional randomized population survey involving 2368 adults, aged ≥20 years. HbA1c was measured on a Bio-Rad 10 system in 1972 subjects.Results: Among 1972 studied subjects, 329 were detected to have prediabetes based on isolated IFG in 125 (6.3%), isolated IGT in 141 (7.1%) and both in 63...

Background: In individuals with primary hyperparathyroidism (PHPT), the utility of preoperative bisphosphonate administration in prevention of post-curative-parathyroidectomy hungry bone syndrome (HBS) and effects on long-term bone accrual are uncertain.Objectives: To estimate the effect of preoperative administration of single infusion of zoledronic acid (ZA) on occurrence of HBS and gain in bone mineral density (BMD) at one year in individuals with PHP...

Introduction: Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy originating from parafollicular C-cells. It accounts for 5% of all thyroid carcinomas.Methods: A retrospective registry-based analysis of demography, clinical manifestation, genetics, management, and outcome of pathologically proven MTC cases presented in a tertiary care hospital in India was done.Results: Among 71 evaluated cases, the mean age of presenta...

Context: Serum IGF-binding protein-3 (IGFBP-3) and molar IGF-I to IGFBP-3 ratio can aid the diagnosis of GH-related diseases. However, their clinical utility is limited by lack of validated reference intervals.Objectives: To establish age-, gender- and Tanner stage-specific reference intervals for IGFBP-3 and IGF-I to IGFBP-3 ratio for Indian ethnicity.Setting and Participants: We conducted a cross-sectional epidemiological study (...

Context: To diagnose and monitor GH-related disorders, serum IGF-I is a cornerstone, but Indian ethnicity based data, following consensus criteria for establishment of normative data are not available.Objectives: To generate normative IGF-I data for chronological age, bone age (BA) [Greulich & Pyle] and Tanner stage for both genders.Setting and Participants: We conducted a cross-sectional epidemiological study for children (age...

Context: Serum IGF-1 levels are of paramount importance for diagnosis and management of growth related disorders. The reference range of IGF- 1 should be ethnicity and Tanner specific. Indian data on the same is scarce and there is a need to develop the same.Objective: To develop age, sex and Tanner based normative reference range of serum IGF-1 level for Indian children and correlate the same with peri-pubertal hormonal parameters.<p class="abstext"...